Medicamentous nefropatija. The beginning of studying of medicinal defeats of kidneys

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Treatment of patients OPN is spent in specialised branches and the centres.

Medicamentous nefropatija

The Defeats of kidneys caused by reception of medicines, unite under the name medicamentous nefropatii.

The Beginning of studying of medicinal defeats of kidneys concerns 40th years of the XX-th century and is connected with introduction in clinical practice sulfanilamidov.

Defeat of kidneys in connection with reception of medicines can be combined with other displays lekarstvennojbolezni, to be its first or unique display.

Medicamentous nefropatii are observed in 13,8% of cases of medicinal illness (E.J.Severov, 1969). Recently the tendency to their increase (D is marked. E. ken, 1968; G.Mazhdrakov, 1973). Frequency medicinal nefropatii in the different countries is various. So, fenatsetinovaja nefropatija Germany is more often registered in the Scandinavian countries, New Zealand, Australia, England. Attracts attention changing spectrum etiologicheskihfaktorov medicinal nefropatii: in the forties a dominant role played sulfanilamidy, in 60-70th years - fenatsetin, antibiotics, protivosudorozhnye means, immunodepressanty (steroids, cytostatics, etc.) - Frequency medicinal nefropatii depends and on a preparation: at application kanamitsina it is observed in 20% of cases, penicillin - in 6,6%, sulfanilamidov - in 5%, fenatsetina from 3,4-4,5% to 50%, heroin - 1%.

Now it is known about 100 preparations promoting razvitijumedikamentoznyh nefropatii.

For the clinical physician of the most rational ordering of all medicamentous nefropatii on clinical nozologii and to a leading syndrome is represented.