the Resulted medicines. Patogenez OPN

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Patogenez OPN is caused in the basic two mechanisms - an ischemia of a kidney and nefrotoksicheskim by the influence, consisting in direct damage kanaltsevogo epitelija. These processes are quite often combined with obturatsiej kanaltsevogo department nefronov. The Leading part of this or that mechanism depends on aetiology OPN.

Patogenez OPN caused I and II groups of the reasons, it is reduced mainly to damage kanaltsevogo epitelija. The given literatures about so nazyvaemojsituatsionnoj nefrotoksichnosti as which understand display nefrotoksichnosti this or that substance only against previous diseases of kidneys Are of interest. To situationally-nefrotoksicheskim substances carry barbituraty, drugs, tranquilizers, and also acetone and gasoline. In patogeneze OPN, caused sulfanilamidami, the mechanical factor - obturatsija kanaltsev crystals sulfanilamidov (medicamentous urolitiaz) matters.

The Mechanism nefrotoksicheskogo actions of preparations, soderzhashchihsoli heavy metals, is reduced to blockade tio-lovyh sulfgidrilnyh groups of cellular proteins. OPN at diseases of kidneys arises in connection with massive adjournment of immune complexes and (or) development glomerulita that leads to deficiency klubochkovoj to a filtration, and also to damage kanaltsevogo epitelija; in case of defeat nephritic interstitsija there is a hypostasis.

Patogenez OPN at mielome is caused by adjournment of paraproteins in all structures of kidneys, and at a gout - uratov, glavnymobrazom in nephritic interstitsii.