Medicamentous nefropatija. Terms of development of defeat of kidneys

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Terms of development of defeat of kidneys at reception of the same preparation are defined by the mechanism of its action in each specific case (a prevalence nefrotiche-skogo or allergic influence).

medicamentous nefropaty it is impossible to consider Patogenez completely studied. It is necessary to note communication patogeneza with etiologicheskim the factor, and also possibility of the mediated influence on kidneys of infringements nejroendokrinnoj regulation (development ADG, aldosterona, etc.), arising, for example, at application indotsida.

According to modern representations, patogenez overwhelming number medicamentous nefropaty it is similar patogenezu diffuznogo a nephrite of an infectious aetiology. Medical products can cause denaturatsiju structures nefrona, mainly bazalnoj membranes therefore are formed autoantitela to bazalnoj to a membrane klubochkov with the subsequent reaction an antigene - an antibody which leads to structure and function infringement nefrona. Krometogo, many medicines are active ingibitorami important enzimnyh systems kanaltsev that can cause development of their irreversible changes. Because of plentiful vaskuljarizatsii kidneys are highly sensitive to the preparations influencing vessels (diuretic, cytostatics, kortikosteroidy, etc.). A number of medicinal substances renders direct nefrotoksicheskoe influence (a dystrophy, nekroz) first of all on epitely kanaltsev (salts of heavy metals, kalija chloride, etc.) . Porazhenieinterstitsija can be result of direct influence or a consequence of allergic reactions. Quite often patogenez medicinal nefropaty includes participation of several mechanisms.